Molybdenum and Tungsten Enzymes

Bioinorganic Chemistry

Edited by Russ Hille, Carola Schulzke, Martin L Kirk

Publication date:

10 October 2016

Length of book:

241 pages

Publisher

Royal Society of Chemistry

ISBN-13: 9781782628828

BOOK DESCRIPTION
TABLE OF CONTENTS

There has been enormous progress in our understanding of molybdenum and tungsten enzymes and relevant inorganic complexes of molybdenum and tungsten over the past twenty years. This set of three books provides a timely and comprehensive overview of the field and documents the latest research.

Building on the first volume that focussed on biochemistry aspects, the second volume in the set focusses on the inorganic complexes that model the structures and reactivity of the active sites of each major group of molybdenum and tungsten enzymes. Special attention is given to synthetic strategies, reaction mechanism and chemical kinetics of these systems. The introductory chapter provides a useful overview and places the topic of the book into a wider context.

This text will be a valuable reference to workers both inside and outside the field, including graduate students and young investigators interested in developing new research programs in this area.

Part I Molybdenum- and tungsten-containing enzymes; Abundance, ubiquity, and evolution of molybdoenzymes; Molybdenum cofactor biosynthesis; Bacterial molybdoenzymes; The prokaryotic Mo/W-bisPGD enzyme family; Enzymes of the xanthine oxidase family; The sulfite oxidase family of Mo enzymes; Nitrogenase; Tungsten-containing enzymes; Part II Introduction and overview of synthetic Mo and W chemistry; Synthesis of mono- and bisdithiolene Mo and W model compounds; Pterin‐inspired Model Compounds of Molybdenum Enzymes; Synthesis of models for the xanthine oxidase family of enzymes; Electron transfer mechanisms in Mo and W compounds; Comparative kinetics of enzymes and models; Models of the metal clusters of nitrogenase; Part III Overview of spectroscopic and electronic studies of Mo and W enzymes; Spectroscopic and electronic structure studies of Mo model compounds and enzymes; Electron paramagnetic resonance studies of molybdenum enzymes; X-ray absorption spectroscopic studies of molybdenum enzymes; Electrochemistry of molybdenum and tungsten enzymes; Computational studies of molybdenum and tungsten enzymes; Nitrogen Fixation in Nitrogenase and Related Small-Molecule Models