Principles of ProteinProtein Association

By (author) Professor Harold P Erickson

Publication date:

19 June 2019

Length of book:

92 pages

Publisher

Institute Of Physics Publishing

Dimensions:

254x178mm
7x10"

ISBN-13: 9780750324106

BOOK DESCRIPTION
TABLE OF CONTENTS

Protein–protein associations are fundamental to biological mechanisms. Developed from lectures given to beginning graduate students in cell and molecular biology, this book presents general principles of thermodynamics and kinetics, and structural principles of protein–protein interface as well as guided reading of informative classic papers. Faculties organizing similar classes, and students and researchers wishing to learn on their own, will also find this book of use.

Chapter 1 Size and Shape of Protein Molecules

Chapter 2 Basic thermodynamics of reversible association

Chapter 3 The nature of the protein-protein bond, à la Chothia and Janin

Chapter 4 The structure of an antibody bound to its protein ligand – lock and key vs induced fit

Chapter 5 The complex of growth hormone with its receptor – one protein interface binds two partners

Chapter 6 The hot spot in protein-protein interfaces

Chapter 7 Cooperativity in protein-protein association and efficiency of bonds

Chapter 8 Kinetics of protein-protein association and dissociation

Chapter 9 Techniques for measuring protein-protein association – use and abuse of ELISA

Chapter 10 Fibronectin, the FNIII domain, and artificial antibodies

Chapter 11 Association of intrinsically disordered proteins – flexible binding partners